2025 | International evidence base | Systematic review and meta-analysis
Baker MB et al. Journal of Clinical Medicine. 2025;14:858.
Methods: Researchers pooled eight studies involving 2,268 patients who received propofol for anesthesia or procedural sedation. Cannabis exposure definitions and clinical settings differed across the included studies.
Findings: Cannabis users received an average of approximately 47 mg more total propofol than nonusers. The authors emphasized low certainty and described the results as a basis for further investigation.
Limitations: Confounding by age, tobacco use, and other characteristics remains possible. Different procedures and exposure patterns limit the meaning of a single pooled dose difference. This estimate is not a dosing rule or a randomized test of disclosure before surgery.