2021 | Canada | Observational case-control study
Imasogie N et al. PLOS ONE. 2021;16:e0248062.
Methods: At one outpatient endoscopy clinic, investigators compared 151 patients reporting cannabis exposure with 167 reporting no history of use. They analyzed propofol requirements and adjusted for measured patient and procedure characteristics.
Findings: Cannabis exposure was associated with higher propofol administration, averaging 0.33 versus 0.18 mg per kilogram per minute. The association remained after adjustment for recorded covariates.
Limitations: Self-reported exposure, a single clinic, and residual confounding limit causal conclusions. A dose association does not prove that cannabis caused a complication or specify the dose any individual patient needs.